the therapeutic journey of benzimidazoles a review

The therapeutic journey of benzimidazoles: a review Bioorg Med Chem. 2012 Nov 1;20(21):6208-36. doi: 10. 1016/j.bmc ... In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing ...

An early review on chemistry of benzimidazole revealed that the very first benzimidazole (2,5 or 2,6-dimethylbenzimidazole) was prepared in 1872 by Hoebrecker through reduction of 2-nitro-4-methylacetanilide ( Scheme 1 ). Several years later Ladenburg obtained the same compound by refluxing 3,4-diamino toluene with acetic acid ( Scheme 1 ).

Introduction. The therapeutic potential of benzimidazole nucleus can be traced back to 1944, when Woolley 1 speculated that benzimidazole can act similar to purines to elicit some biological responses. Five years later, Brink2, 3 identified 5,6-dimethylbenzimidaozle as degradation product of vitamin B 12 and subsequently found some of its ...

2015. TLDR. This work systematically gives a comprehensive review in current developments of benzimidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti‐inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial ...

Benzimidazole nucleus possess a wide range of pharmacological activities such as antitumor, antiinflammatory, antimicrobial, antiviral, and antihypertensive (Aragón-Muriel et al., 2021; Bansal ...

Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. has made it an indispensable anchor for ...

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Boiani and Gonález have reviewed the imidazole and benzimidazole derived molecules and their N-oxides with reference to their antitumoral, antiparasitic, antiviral and antimicrobial activities.9 Recently, a review on therapeutic potential of benzimidazole nucleus appeared with a meager 50 references for all activities10 but no comprehensive ...

Benzimidazoles have a structure that resembles naturally occurring purine nucleotides, which allows them to easily contact the biopolymers within the living system 28.The benzimidazole pharmacophore can form hydrogen bonds, amide-ring and aromatic-ring interactions, hydrophobic interactions, van der Waals forces, polar contact and pi-bonds with the targets (Table 1, Fig. 1).

Therapeutic Efficacy of Benzimidazole and Its Analogs: An Update. N. Jeelan Basha Department of Chemistry, ... This review covers the synthesis of benzimidazole analogs by feasible methods from our laboratory. Also, the present review explores the recent reports on benzimidazole analogs designed as antibacterial, antifungal, anticancer, and ...

Benzimidazole, a key heterocycle in therapeutic chemistry, and its derivatives, are recently mentioned in the literature as corrosion inhibitors for steels (CS, MS), pure metals (Fe, Al, Cu, Zn) and alloys. ... Bansal Y, Silakari O (2012) The therapeutic journey of benzimidazoles: a review. Eur J Med Chem 20:6208-6236.

Different benzimidazole derivatives as drugs for different therapeutic field. ... The therapeutic journey of benzimidazoles: A review. Bioorganic Med. Chem., 20 (21) (2012), pp. 6208-6236, 10.1016/j.bmc.2012.09.013. View PDF View article View in Scopus Google Scholar. Bistrović et al., 2018.

Key takeaway: 'Benzimidazole nucleus is an essential anchor for developing new therapeutic agents, with diverse substitution patterns providing a wide spectrum of biological activities.' ... The therapeutic journey of benzimidazoles: a review. Y. Bansal, O. Silakari. Nov 1, 2012. Cite. Share. Citations. 553. Citations. Quality indicators ...

Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few.

Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. ... The therapeutic journey of benzimidazoles: a review. Bansal Y, Silakari O. Bioorg Med Chem, 20(21):6208-6236, 17 Sep 2012 Cited by: 159 articles | PMID: 23031649 ...

The therapeutic journey of benzimidazoles: a review. Bioorganic and Medicinal Chemistry, 20 (21) (2012), pp. 6208-6236. View PDF View article View in Scopus Google Scholar ... Novel research strategies of benzimidazole derivatives: a review. Mini Reviews in Medicinal Chemistry, 13 (10) (2013), pp. 1421-1447. CrossRef View in Scopus Google Scholar

Benzimidazoles got an increased attention due to their outstanding bioavailability, stability and important biological efficiency. This article reveals and discuss about typical synthetic methods established for benzimidazole class of scaffolds &their biological and therapeutic applications illustrated on variety of benzimidazole products.

Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few.

benzimidazole is the most well-known. It functions as an axial ligand for cobalt in vitamin B 12 and has a variety of other pharmacological actions.[2] NH N Due to their unique structural features and electron-rich environments, benzimidazole-containing drugs bind to a wide variety of therapeutic targets with a wide range of biological activities.